Response to a booster dose of DTPa-IPV at 4 years old and persistence of immunity following a new approach to an optimised pertussis vaccination schedule in healthy infants: a follow-up study of optimising pertussis vaccination in infants – a new approach
Why this study

Pertussis is one of the most contagious vaccine preventable diseases. Australia has recently experienced an epidemic of pertussis. Infants too young to be fully vaccinated and children who are aged 3–5 years are at highest risk for becoming severely unwell from whooping cough.  

What do we want to achieve

Compare the immune protection levels at 18 to 36 months and at 4 years old between children who received the alternate pertussis vaccination schedule and those who received the standard vaccination schedule. We will also aim to compare the immune responses after the 4-year -old's booster dose of the diphtheria-tetanus-pertussis-polio vaccine 1 month after vaccination.  

How are we doing it

Patients who completed the Optimising pertussis vaccination infants study are recruited to have serology testing before the 4-year DTP-IPV vaccine and 1 month after to determine the immune protection to diphtheria, tetanus, pertussis and polio. 

Where are we up to

Data analysis in progress. 

Last updated August 2020