Essential research to inform the impact of immunosuppressive medications taken during pregnancy on maternal and infant immune responses to vaccines
Why this study

Maternal vaccination against influenza and pertussis is our primary strategy to prevent these infections in young infants. However, information on the safety and immunogenicity of influenza and pertussis vaccination in pregnant women taking immunosuppressive medications and immune responses to vaccines in their infants is lacking because as a group they are excluded from drug trials.

What do we want to achieve

Assess the safety and immunogenicity of influenza and pertussis vaccination in pregnant women taking biological disease modifying anti-rheumatic drugs (bDMARDs) and the immune responses to vaccines in their infants.

How are we doing it

Prospective multicentre recruitment of pregnant women on immunosuppressive medication to determine antibody responses to acellular pertussis (dTpa) and influenza vaccines during pregnancy and antibody responses in infants of these mothers following their routine infant vaccinations through serology testing.

Where are we up to

Recruiting (contact Dr Ketaki Sharma at ketaki.sharma@health.nsw.gov.au for more information) 

Last updated June 2020