Characterising clinical presentation and outcomes of children presenting with seizures following vaccination
Why this study

Febrile seizure risk following vaccination within a defined period after vaccination when a fever peak is well recognised. Only recently, however, have afebrile seizures and prolonged seizures been reported following vaccinations. In a landmark Australian study, SCN1A-associated Dravet syndrome was associated with post-vaccination seizures in the first year of life, especially within 48 hours of DTP vaccination. Little is known, however, on the proportion of children with status epilepticus following vaccination, whether they proceed to have genetic testing and whether these children continue to have their routine vaccinations in a timely manner.

What do we want to achieve

Determine the proportion of children who present with status epilepticus following vaccination subsequently get diagnosed with Dravet syndrome and what their re-vaccination outcomes are

How are we doing it

Retrospective clinical chart review of children presenting to tertiary paediatric hospitals with status epilepticus following vaccination or to a Specialist Immunisation Clinic with a history of seizures to determine their clinical progression and revaccination outcomes. 

Where are we up to

Data analysis in progress.

Last updated June 2020