Safety and immunogenicity of Q fever vaccine in children 10 to 15 years old
Why this study

Q fever is a highly infectious disease caused by Coxiella Burnettii, with more than 450 cases notified in Australia annually. There is an effective Q fever vaccine, QVax, which is recommended for those considered to be in “occupational at risk” groups, such as abattoir workers, veterinarians and farmers. Currently QVax is only licensed for those older than 15 years, as initial trials did not include children. Therefore, children younger than 15 years who are at risk of contracting Q fever, because they live on farms, near abattoirs or are children of “at risk” workers, are not recommended to be vaccinated. 

What do we want to achieve

Determine the safety and immunogenicity (immune responses) of a Q fever vaccine in children aged 10 to 15 years old. 

How are we doing it

Healthy children aged 10–15 years who are at potential risk for Q fever are recruited to receive QVax, following the routine pre-vaccination skin test and serology screening. Serial serology testing performed 7 and 13 months following vaccination. 

Where are we up to

Recruiting (contact Associate Professor Nicholas Wood at nicholas.wood@health.nsw.gov.au for more information)

Last updated August 2020