BCG vaccination to reduce the impact of COVID-19 in healthcare workers 

The BCG vaccination to Reduce the impact of COVID-19 in healthcare workers following Coronavirus Exposure (BRACE) trial was launched by Murdoch Children’s Research Institute (MCRI). The clinical trials teams at NCIRS and Kids Research, Sydney Children’s Hospital Network will be coordinating the trial in NSW with the other sites across Sydney that will be involved, including Westmead Hospital, Sydney Children’s Hospital Randwick, Prince of Wales Hospital and St Vincent’s Hospital.

Why this study

Healthcare workers are at increased risk of contracting COVID-19, caused by SARS-CoV-2. Currently, there are no vaccines or proven preventative interventions available to protect healthcare workers.

The BCG vaccine is one of the most widely used vaccines in the world, given to over 130 million babies worldwide each year. In addition to preventing tuberculosis, this vaccine also boosts immunity against a variety of other infections.

What do we want to achieve

The purpose of the BRACE trial is to find out whether BCG vaccination protects against COVID-19 or reduces severity of COVID-19 in Australian healthcare workers.

How are we doing it

In total, the randomised controlled trial will test 10,000 healthcare workers across Australia, and other countries, including the Netherlands and Spain. Half of the participants will receive the BCG vaccine while the other half will receive a placebo. Participants will then be tracked over a period of 12 months to record if they contract COVID-19 and the severity of their symptoms.

Where are we up to

Recruiting healthcare workers (Visit the MCRI website for more information to register to participate in the trial.)

Last updated October 2020